Do interleukin-28B single nucleotide polymorphisms influence the natural history of chronic hepatitis B?
نویسندگان
چکیده
Results A total of 49 cases fit the inclusion criteria. Most were male (90%), with a median (IQR) age of 42.6 (39-46.7) years-old. Eighteen (36.7%) were or had been chronic infected by HCV. Among HBsAg+ patients, 19 (41.3%) were HBeAg+ and 13 (26.5%) were superinfected by the hepatitis delta virus (HDV). No differences were found in the distribution of CC genotypes when comparing patients with chronic hepatitis B and those who spontaneously cleared HBsAg (59.2% vs 44.9%, respectively; p=0.3). Conclusions There is no evidence for a beneficial role of the IL-28B CC genotype on the development of chronic hepatitis B in HIV-coinfected patients.
منابع مشابه
بررسی ارتباط پلیمورفیسم (rs1800872A/C) ژن اینترلوکین 10 با ابتلا به عفونت مزمن هپاتیت B
Background and Aim: Cytokines are believed to play an important role in the regulation of cellular immune response in hepatitis B virus infection. Interleukin 10 is a member of cytokine family. The overall expression of these molecules is mainly controlled by single nucleotide polymorphisms at specific sites on the promoter region of the Interleukin 10 gene. The aim of this study was to a...
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